Here, we describe a biomimetic microsystem that reconstitutes the critical functional alveolar-capillary
interface of the human lung. This bioinspired microdevice reproduces complex …

Angiogenesis is controlled by physical interactions between cells and extracellular matrix
as well as soluble angiogenic factors, such as VEGF. However, the mechanism by which …

The Rho GDP dissociation inhibitor (GDI) forms a complex with the GDP-bound form of the
Rho family small G proteins and inhibits their activation. The GDP-bound form complexed …

Transcriptional regulation contributes to the maintenance of pluripotency, self-renewal and
differentiation in embryonic cells and in stem cells. Therefore, control of gene expression at …

Fundamental investigations of human biology, and the development of therapeutics, commonly
rely on 2D cell-culture systems that do not accurately recapitulate the structure, function, …

Current in vitro hematopoiesis models fail to demonstrate the cellular diversity and complex
functions of living bone marrow; hence, most translational studies relevant to the …

Morphogenesis is the remarkable process by which cells self-assemble into complex tissues
and organs that exhibit specialized form and function during embryological development. …

The effectiveness of stem cell therapies has been hampered by cell death and limited
control over fate. These problems can be partially circumvented by using macroporous …

An in vitro model of the human kidney glomerulus—the major site of blood filtration—could
facilitate drug discovery and illuminate kidney-disease mechanisms. Microfluidic organ-on-a-…

Cyclic mechanical strain produced by pulsatile blood flow regulates the orientation of
endothelial cells lining blood vessels and influences critical processes such as angiogenesis. …