Current dosing algorithms do not account for genetic and environmental factors for warfarin
dose determinations. This study investigated the contribution of age, CYP2C9 and VKORC1 …

Background The level of anticoagulation in response to a fixed-dose regimen of warfarin is
difficult to predict during the initiation of therapy. We prospectively compared the effect of …

Background Alcohol and illicit drug use are increasing among school children and young
adults in the UK. Such increases have also been noted among university students and there is …

Work related stress and anxiety may have a profound effect on an individual’s wellbeing. In
the case of doctors this may also affect patient care. This study measured stress, anxiety, and …

Alcohol, illicit drug use, and other lifestyle variables, as well as stress, anxiety and personality
were evaluated in 194 first year medical students. 45% of the students reported drinking …

Drinking and illicit drug use were assessed longitudinally in a cohort of medical students who
were surveyed in the second and fifth year of their undergraduate studies and after 1 year …

Objective Our objective was to assess the contribution of CYP2C9 genotype, age, body size,
and vitamin K and lipid status to warfarin dose requirements. Methods Patients with stable …

Of 125 patients aged 65 years or over, with atrial fibrillation taking warfarin for at least 12
months, with a standard deviation (SD) of prothrombin time, expressed as the International …

Patients receiving warfarin who have unstable control of anticoagulation have a significantly
lower intake of dietary vitamin K compared with their stable counterparts. We hypothesized …

The narrow therapeutic range and wide interpatient variability in dose requirement make
anticoagulation response to coumarin derivatives unpredictable. As a result, patients require …