Jim Jingjun Huang

Poor water solubility of many new chemical entities in pharmaceutical industry’s pipeline as well as API in many marketed drugs present a major challenge in developing and optimizing safe and bioavailable dosage forms for testing on animals or human. Current solubilization and drug delivery technologies for water insoluble drug are summarized. The key considerations in rational design of safe and bioavailable drug delivery systems are explained. Applications of drug delivery technologies such as solid dispersion, nanoemulsion, and nanoparticles that enable testing of compound safety and efficacy at discovery, clinical and life cycle management stages are presented.