This study was conducted in order to compare the bioavailability of two film coated tablets containing 25 mg of quetiapine. Twenty-four subjects were enrolled and completed in a single center, randomized, single dose, open label, two-way crossover study with a one-week washout period. Plasma samples were collected up 24 hours following drug administration and quetiapine was determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS) method with turbo ion spray mode. Pharmacokinetic parameters used for bioequivalence assessment were AUC0-t, AUC0-∞ and Cmax. The 90% confidence intervals obtained by analysis of variance for AUC0-t, AUC0-∞ and Cmax were 80.39-99.64%, 80.26-99.51% and 83.23-109.20%, respectively. These results were all within the range of 80.00-125.00%. Bioequivalence between formulations was concluded both in terms of rate and extent of absorption.
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