Comparative study between central subfoveal Choroidal Thickness in Diabetic retinopathy and control by Spectral domain optical coherent tomography Nagla Hassan Aly MD, Assistant professor at Memorial Institute for ophthalmic researches (MIOR) ,Giza Egypt. 01005293288, naglahas@yahoo.com. Noura Khalid Al Qassimi ,German Board , ophthalmology Consultant at Sheik Khalifa medical city ,Abu Dhabi ,UAE. n_alqassimi@mail.com Key wards : correlation, Normal , OCT, early diabetic retinopathy , subfoveal choroidal thickness . Title Comparative study between central subfoveal Choroidal Thickness in Diabetic retinopathy and normal by Spectral domain optical coherent tomography Purpose: To compare subfoveal choroidal thickness (SCT) measurements by commercially available spectral-domain optical coherence tomography instruments between healthy eyes and moderate non proliferative diabetic retinopathy without macular edema. Patients &Methods: 80 eyes of patients whom ages ranged from 45-55 years both sex ,were subjected to full ophthalmological examination including slit lamp biomicroscopy and FA for staging of the Disease( moderate NPDR without macular edema ) -best corrected visual acuity not less 20/40. - IOP less than 21. -Choroidal thickness (CT) was measured from the outer edge of the hyperreflective retinal pigment epithelium to the inner sclera at subfoveal region. Accordingly the patients were divided into 2 groups : - • Group (1) 40 eyes of normal control. • Group (2) 40 eyes with moderate non proliferative diabetic retinopathy type 2 where The mean central subfoveal choroidal thickness was measured manually by SD OCT ( Topcon –seven lines protocol ) . Results :Subfoveal choroidal thickness showed significant decrease in moderate NPDR compared to control group. Conclusion : Mean central subfoeval choroidal thickness is decreased in moderate non proliferative diabetic retinopathy than normal control using spectral domain OCT.