Comprehensive Management of Cancer Patients with Pain: Developing the Basic Principle of Cancer Pain Management among Nursing Staff on Acute Medical Setting Purpose Pain is one of the commonest symptoms in patients with cancer occurring in as many as 90% of Patients during their illness. Pain is a complex phenomenon, which can be exacerbated by numerous others Factors. This paper discusses the understanding of cancer pain among nursing on acute medical setting and Develop the principle of cancer pain management which basically the knowledge not sufficient to manage Patient. Methods Education Activity was held on acute medical unit where the cancer patient was located. Target Participants were nursing staff on the unit using the different teaching strategies for acute medical Nursing staff to understand the principles of cancer pain for example: case presentation, power point Presentation and activity based … etc. the education session conducted once every week and include all Nursing staff on duty. In this paper I use Descriptive approach to collect the data about the level of cancer Pain knowledge by using closed – ended questions (Multiple – choice Questions) before the education Session and use same question to re?evaluated the level of improvement. Results The participants demonstrated a 95% improvement in cancer pain knowledge were sustained at Two month. And were maintained at the six?month follow?up by observing the bedside practice and self-reporting. Participants indicated that the knowledge gained positively influenced their clinical practice. Conclusion Comprehensive management of cancer patients with pain is achieved among acute medical Nursing staff by deliver the education they need to understand the cancer pain. An education session for nursing staff on acute medical improved understanding about cancer pain Management. The nurses also reported having made improvements in the care provided to patients and Careers