Cheol-Min Ghim earned his Ph.D. in theoretical physics from Seoul National University in 2003. After postdoctoral research at Center for Theoretical Physics, SNU (2003-2004), Center for Theoretical Biological Physics, University of California, San Diego (2004-2005), and Levich Institute of Physico-Chemical Hydrodynamics, New York (2005-2006), he had been working for Lawrence Livermore National Laboratory, US Department of Energy (2006-2009). He joined the faculty of UNIST in 2009 as an Assistant Professor of School of Nano-Bioscience & Chemical Engineering and Interdisciplinary School of Green Energy. He holds Visiting Scholar status in US DOE Lawrence Livermore National Laboratory since 2010.
Objectives: We report on a patient with dementia following herpes encephalitis who showed injury of a part of the Papez circuit (thalamocingulate tract between the anterior thalamic nuclei and the cingulate gyrus) on diffusion tensor tractography (DTT). Case report: A 45-year-old male had suffered from drowsy mentality, fever, and headache for three days. The patient was diagnosed as herpes encephalitis based on the clinical manifestations and the results of cerebrospinal fluid analysis, electroencephalography, and brain MRI. The patient’s symptoms almost disappeared by administration of acyclovir for two weeks. However, the results of neuropsychological testing at three months after onset indicated dementia. On the Mini-Mental Status examination, the patient scored 21/30. Results of the neuropsychological test performed at three months after onset showed verbal memory impairment on the Memory Assessment Scale (68 [2%ile]). In addition, the patient’s total score on the Memory Assessment Scale (84 [14%ile]) was relatively low compared with his total intelligence quotient on the Wechsler Adult Intelligence Scale (123 [94%ile]). Results: On three-month DTT, the neural tracts of the Papez circuit (fornix, cingulum, mamillothalamic tract, and thalamocingulate tract) were reconstructed in both cerebral hemispheres; however, the right thalamocingulate tract between the anterior thalamic nuclei and cingulate gyrus was disrupted. Conclusion: Our results indicate injury of the right thalamocingulate tract following viral encephalitis in this patient. We believe that the patient’s memory impairment was attributed, at least in part, to injury of the right thalamocingulate tract. Our results suggest the necessity of evaluation of the Papez circuit using DTT in patients with symptoms of dementia following encephalitis.
Jaqueline Botelho da Ponte interests include in neurology field, and the nutritional intervention with dementia diagnosis and treatment.
Patients with severe dementia, usually have problems the swallowing that leads them to have progressive weight loss . The aim of this study was to evaluate the profile of these nutritionally patients with severe dementia. Nutritionally n = 62 elderly patients were assessed ,all in CDR 3-attended the clinic Dementia UNIFESP / EPM , for the year 2013. The results indicate that 50 elderly were malnourished -Weight Md : 52.56 kg , height Md : 1,55 m , Body Mass Index - BMI Md : 21.21 kg/m2 , Arm Circumference - AC Md = 25 , 28 cm , triceps skinfold – TS Md = 11.39 mm , Circunfereência Muscular Arm - AMB Md = 21.70 cm Circumference and Calf - CC Md = 30.63 cm , valid for screening of nutritional diagnostic measures . Only 12 patients were normal weight - Weight Md = 52.58 kg , height = 1.55 m Md , Md BMI = 21.32 kg/m2 , PCT md = 11.53 cm , AC Md = 25.37 cm , AMB Md = 21.74 cm and CC Md= 30.64. Use beyond the anthropometric data , quality data supply, which indicates a diet low in calories and protein for all patients . Despite the modest sample be concluded that the findings corroborate the literature that emphasizes malnourished in severe stage of the disease , which leads us to invest in early nutrition.